Anna Maria Luisa de’ Medici, the last descendant of the illustrious Medici family, played a crucial role in preserving Florence’s artistic and cultural heritage. Thanks to her foresight and determination, the treasures of the Medici dynasty remained in the city, ensuring that Florence would continue to shine as one of the world’s most important centers of art and history. Her story is one of intelligence, resilience, and a deep love for her homeland.

The Last of the Medici
Born in 1667 in Florence, Anna Maria Luisa was the only daughter of Grand Duke Cosimo III de’ Medici and Marguerite Louise d’Orléans. Raised in the grandeur of the Medici court, she received an exceptional education, particularly in the arts, literature, and politics. Unlike many noblewomen of her time, she was highly involved in cultural and political affairs, demonstrating a keen intellect and strong will.
In 1691, she married Johann Wilhelm, Elector Palatine of the Rhine, and moved to Düsseldorf. Although she lived abroad for many years, she remained deeply connected to Florence, maintaining strong ties with her homeland. Her marriage, however, was childless, and when her husband passed away in 1716, she returned to Florence, where she faced the growing uncertainty surrounding the future of the Medici dynasty.
A Legacy of Cultural Protection
By the time Anna Maria Luisa returned to Florence, the Medici family was on the brink of extinction. Without an heir, the Grand Duchy of Tuscany was set to pass into the hands of the House of Lorraine. Realizing that this transition could lead to the dispersal of the Medici’s vast collection of art, she took a decisive step that would change the course of history.
In 1737, she signed the “Family Pact”, an agreement with the new rulers of Tuscany that ensured the Medici treasures (including paintings, sculptures, books, jewels, and other invaluable works of art) would remain in Florence forever. This act guaranteed that the artistic heritage accumulated by generations of the Medici family would not be taken to foreign lands but would stay in the city to be admired by future generations.
Thanks to her vision, today we can still admire masterpieces by Michelangelo, Botticelli, Caravaggio, and Leonardo da Vinci in Florence’s museums and palaces, such as the Uffizi Gallery, Pitti Palace, and the Medici Chapels.
Discovering Florence with City Sightseeing Italy
Florence, the city that owes so much to Anna Maria Luisa de’ Medici, is a must-visit destination for lovers of art, history, and culture. To explore its magnificent landmarks with ease, the City Sightseeing Italy Hop-On Hop-Off Bus is the perfect choice.
This convenient and flexible service allows you to visit Florence at your own pace, stopping at key locations such as the Uffizi Gallery, the Pitti Palace, and the stunning Ponte Vecchio. You can also admire the Medici Chapels, where Anna Maria Luisa herself is buried, honoring the dynasty she fought so hard to preserve.
With panoramic views of Florence’s Renaissance beauty, the hop-on hop-off bus makes it easy to navigate the city while learning about its rich history through the informative audio guide available onboard.
Anna Maria Luisa de’ Medici passed away in 1743, marking the end of the Medici dynasty. However, her legacy remains alive in every masterpiece that still graces Florence’s museums and palaces. Without her determination and love for her city, the world might have lost some of its greatest artistic treasures.
Visiting Florence today is a tribute to her extraordinary vision. As you explore the city’s wonders, whether by foot or aboard the City Sightseeing Italy Hop-On Hop-Off Bus, take a moment to appreciate the woman who made it all possible—the last Medici, Anna Maria Luisa.